Genetic markers, called SNPs, associated with breast cancer were identified in genome-wide association studies (GWAS) involving more than 50,000 women. These common SNPs, obtained from DNA in saliva, are different from and unrelated to the BRCA 1 and 2 familial breast cancer genes that only 7% of women have. These seven SNPs apply to many more women, particularly to those 70% of women without a family history of breast cancer.
Seven known risk factors, such as age, age at first menstrual cycle, age at first live birth, family history and biopsy history are used to generate a clinical risk in the National Cancer Institute's Breast Cancer Risk Assessment Tool (BCRAT) called the Gail Score.
Combining this genetic information from a noninvasive buccal swab with the clinical factors in the Gail Score gives the 5-Year risk and the Lifetime risk. The results of the test allow us to make recommendations that align with American Cancer Society (ACS) and The American Society of Clinical Oncologists (ASCO) recommendations for screening and treatment in low, intermediate and high risk individuals. Furthermore, the BREVAGen test reclassifies 64% of intermediate Gail Scores (about 30%) to either low or high risk.
SO WE HAVE THE INFORMATION AND KNOW WHAT TO DO WITH IT!
Who should take the test:
- anyone who wants to know her personal risk
- anyone concerned about an elevated breast cancer risk
- high risk not qualifying for BRCA 1 & 2 testing
- negative BRCA 1 & 2 test
- intermediate Gail Risk
- anyone who has had a breast biopsy or aspiration.
Call 512-451-5788 to get yours today.
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